Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas.

ABSTRACT:

Background

Gliomas are the most common type of all central nervous system tumors. Almost all patients diagnosed with these tumors have a poor prognostic outcome. We aimed to identify novel glioma prognosis-associated candidate genes.

Methods

We applied WebArrayDB software to span platform integrate and analyze the microarray datasets. We focused on a subset of the significantly up-regulated genes, the minichromosome maintenance (MCM) family. We used frozen glioma samples to predict the relationship between the expression of MCMs and patients outcome by qPCR and western blot.

Results

We found that MCMs expression was significantly up-regulated in glioma samples. MCM2-7 and MCM10 expressions were associated with WHO tumor grade. High MCM2 mRNA expression appeared to be

SUBMITTER: Hua C 

PROVIDER: S-EPMC4223428 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature