Integrative analysis of GWASs, human protein interaction, and gene expression identified gene modules associated with BMDs.

ABSTRACT:

Context

To date, few systems genetics studies in the bone field have been performed. We designed our study from a systems-level perspective by integrating genome-wide association studies (GWASs), human protein-protein interaction (PPI) network, and gene expression to identify gene modules contributing to osteoporosis risk.

Methods

First we searched for modules significantly enriched with bone mineral density (BMD)-associated genes in human PPI network by using 2 large meta-analysis GWAS datasets through a dense module search algorithm. One included 7 individual GWAS samples (Meta7). The other was from the Genetic Factors for Osteoporosis Consortium (GEFOS2). One was assigned as a discovery dataset and the other as an evaluation dataset, and vice versa.

Results

In tota

SUBMITTER: He H 

PROVIDER: S-EPMC4223444 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature