Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.

ABSTRACT: Cancer is responsible for many deaths and is a major source of healthcare expenditures. The identification of new, non-invasive biomarkers might allow improvement of the direct diagnostic or prognostic ability of already available tools. Here, we took the innovative approach of interrogating the activity of exopeptidases in the serum of cancer patients with the aim of establishing a distinction based on enzymatic function, instead of simple protein levels, as a means to biomarker discovery. We first analyzed two well-characterized mouse models of prostate cancer, each with a distinct genetic lesion, and established that broad exopeptidase and targeted aminopeptidase activity tests reveal proteolytic changes associated with tumor development. We also describe new peptide-based freeze-frame

SUBMITTER: Nazarian A 

PROVIDER: S-EPMC4223493 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature