Personalized prostate cancer screening among men with high risk genetic predisposition- study protocol for a prospective cohort study.

ABSTRACT:

Background

Prostate cancer screening among the general population is highly debatable. Nevertheless, screening among high-risk groups is appealing. Prior data suggests that men carrying mutations in the BRCA1& 2 genes may be at increased risk of developing prostate cancer. Additionally, they appear to develop prostate cancer at a younger age and with a more aggressive course. However, prior studies did not systematically perform prostate biopsies and thus cannot determine the true prevalence of prostate cancer in this population.

Methods

This will be a prospective diagnostic trial of screening for prostate cancer among men with genetic predisposition. The target population is males (40-70 year old) carrying a BRCA1 and/or BRCA2 germ line mutation. They will be identified via

SUBMITTER: Margel D 

PROVIDER: S-EPMC4223504 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature