Using haplotypes for the prediction of allelic identity to fine-map QTL: characterization and properties.

ABSTRACT:

Background

Numerous methods have been developed over the last decade to predict allelic identity at unobserved loci between pairs of chromosome segments along the genome. These loci are often unobserved positions tested for the presence of quantitative trait loci (QTL). The main objective of this study was to understand from a theoretical standpoint the relation between linkage disequilibrium (LD) and allelic identity prediction when using haplotypes for fine mapping of QTL. In addition, six allelic identity predictors (AIP) were also compared in this study to determine which one performed best in theory and application.

Results

A criterion based on a simple measure of matrix distance was used to study the relation between LD and allelic identity prediction when using haplot

SUBMITTER: Jacquin L 

PROVIDER: S-EPMC4223544 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature