MicroRNA profile in very young women with breast cancer.

ABSTRACT:

Background

Breast cancer is rarely diagnosed in very young women (35 years old or younger), and it often presents with distinct clinical-pathological features related to a more aggressive phenotype and worse prognosis when diagnosed at this early age. A pending question is whether breast cancer in very young women arises from the deregulation of different underlying mechanisms, something that will make this disease an entity differentiated from breast cancer diagnosed in older patients.

Methods

We performed a comprehensive study of miRNA expression using miRNA Affymetrix2.0 array on paraffin-embedded tumour tissue of 42 breast cancer patients 35 years old or younger, 17 patients between 45 and 65 years old and 29 older than 65 years. Data were statistically analyzed by t-tes

SUBMITTER: Pena-Chilet M 

PROVIDER: S-EPMC4223555 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature