Ontology highlight
ABSTRACT:
SUBMITTER: DeRan M
PROVIDER: S-EPMC4223634 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Cell reports 20141016 2
Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformation. These effects require the central metabolic sensor AMP-activated protein kinase (AMPK) and the upstream Hippo pathway components Lats1/Lats2 and angiomotin-like 1 (AMOTL1). Furthermore, we show that ...[more]