Comparative genome analysis of Wolbachia strain wAu.

ABSTRACT:

Background

Wolbachia intracellular bacteria can manipulate the reproduction of their arthropod hosts, including inducing sterility between populations known as cytoplasmic incompatibility (CI). Certain strains have been identified that are unable to induce or rescue CI, including wAu from Drosophila. Genome sequencing and comparison with CI-inducing related strain wMel was undertaken in order to better understand the molecular basis of the phenotype.

Results

Although the genomes were broadly similar, several rearrangements were identified, particularly in the prophage regions. Many orthologous genes contained single nucleotide polymorphisms (SNPs) between the two strains, but a subset containing major differences that would likely cause inactivation in wAu were identified, i

SUBMITTER: Sutton ER 

PROVIDER: S-EPMC4223829 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature