Impact of remote ischemic preconditioning preceding coronary artery bypass grafting on inducing neuroprotection (RIPCAGE): study protocol for a randomized controlled trial.

ABSTRACT:

Background

Neurological complications after cardiac surgery have a profound impact on postoperative survival and quality of life. The increasing importance of strategies designed to improve neurological outcomes mirrors the growing risk burden of the contemporary cardiac surgical population. Remote ischemic preconditioning (RIPC) reduces adverse sequelae of ischemia in vulnerable organs by subjecting tissues with high ischemic tolerance to brief periods of hypoperfusion. This trial will evaluate the neuroprotective effect of RIPC in the cardiac surgical arena, by employing magnetic resonance imaging (MRI) and neurocognitive testing.

Methods

Patients scheduled for elective coronary artery bypass grafting with the use of cardiopulmonary bypass will be screened for the study. E

SUBMITTER: Gasparovic H 

PROVIDER: S-EPMC4223850 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature