Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.
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ABSTRACT:
SUBMITTER: Rappold PM
PROVIDER: S-EPMC4223875 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo.
Rappold Phillip M PM Cui Mei M Grima Jonathan C JC Fan Rebecca Z RZ de Mesy-Bentley Karen L KL Chen Linan L Zhuang Xiaoxi X Bowers William J WJ Tieu Kim K
Nature communications 20141105
Mitochondrial dysfunction has been reported in both familial and sporadic Parkinson's disease (PD). However, effective therapy targeting this pathway is currently inadequate. Recent studies suggest that manipulating the processes of mitochondrial fission and fusion has considerable potential for treating human diseases. To determine the therapeutic impact of targeting these pathways on PD, we used two complementary mouse models of mitochondrial impairments as seen in PD. We show here that blocki ...[more]
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