Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is heritable and neurodevelopmental with unknown causes. The serotonergic and oxytocinergic systems are of interest in autism for several reasons: (i) Both systems are implicated in social behavior, and abnormal levels of serotonin and oxytocin have been found in people with ASD; (ii) treatment with selective serotonin reuptake inhibitors and oxytocin can yield improvements; and (iii) previous association studies have linked the serotonin transporter (SERT; SLC6A4), serotonin receptor 2A (HTR2A), and oxytocin receptor (OXTR) genes with ASD. We examined their association with high functioning autism (HFA) including siblings and their interaction.

Methods

In this association study with HFA children (IQ > 80), siblings, and controls, pa

SUBMITTER: Nyffeler J 

PROVIDER: S-EPMC4223888 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature