Iron and neurodegeneration in the multiple sclerosis brain.

ABSTRACT:

Objective

Iron may contribute to the pathogenesis and progression of multiple sclerosis (MS) due to its accumulation in the human brain with age. Our study focused on nonheme iron distribution and the expression of the iron-related proteins ferritin, hephaestin, and ceruloplasmin in relation to oxidative damage in the brain tissue of 33 MS and 30 control cases.

Methods

We performed (1) whole-genome microarrays including 4 MS and 3 control cases to analyze the expression of iron-related genes, (2) nonheme iron histochemistry, (3) immunohistochemistry for proteins of iron metabolism, and (4) quantitative analysis by digital densitometry and cell counting in regions representing different stages of lesion maturation.

Results

We found an age-related increase of iron in th

SUBMITTER: Hametner S 

PROVIDER: S-EPMC4223935 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature