Fractalkine is a "find-me" signal released by neurons undergoing ethanol-induced apoptosis.

ABSTRACT: Apoptotic neurons generated during normal brain development or secondary to pathologic insults are efficiently cleared from the central nervous system. Several soluble factors, including nucleotides, cytokines, and chemokines are released from injured neurons, signaling microglia to find and clear debris. One such chemokine that serves as a neuronal-microglial communication factor is fractalkine, with roles demonstrated in several models of adult neurological disorders. Lacking, however, are studies investigating roles for fractalkine in perinatal brain injury, an important clinical problem with no effective therapies. We used a well-characterized mouse model of ethanol-induced apoptosis to assess the role of fractalkine in neuronal-microglial signaling. Quantification of apoptotic debris

SUBMITTER: Sokolowski JD 

PROVIDER: S-EPMC4224129 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature