Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB.

ABSTRACT:

Background

Bipolar disorder (BD) is a highly heritable disease. While genome-wide association (GWA) studies have identified several genetic risk factors for BD, few of these studies have investigated the genetic etiology of specific disease subtypes. In particular, BD is positively associated with eating dysregulation traits such as binge eating behavior (BE), yet the genetic risk factors underlying BD with comorbid BE have not been investigated.

Methods

Utilizing data from the Genetic Association Information Network study of BD, which included 729,454 single nucleotide polymorphisms (SNPs) genotyped in 1001 European American bipolar cases and 1034 controls, we performed GWA analyses of bipolar subtypes defined by the presence or absence of BE history, and performed a case-o

SUBMITTER: Winham SJ 

PROVIDER: S-EPMC4224146 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature