Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure.

ABSTRACT:

Objectives

The aim of this study was to determine whether biomarkers of myocardial stress and fibrosis improve prediction of the mode of death in patients with chronic heart failure.

Background

The 2 most common modes of death in patients with chronic heart failure are pump failure and sudden cardiac death. Prediction of the mode of death may facilitate treatment decisions. The relationship between amino-terminal pro-brain natriuretic peptide (NT-proBNP), galectin-3, and ST2, biomarkers that reflect different pathogenic pathways in heart failure (myocardial stress and fibrosis), and mode of death is unknown.

Methods

HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) was a randomized controlled trial of exercise training versus us

SUBMITTER: Ahmad T 

PROVIDER: S-EPMC4224312 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature