Specific modifications of histone tails, but not DNA methylation, mirror the temporal variation of mammalian recombination hotspots.

ABSTRACT: Recombination clusters nonuniformly across mammalian genomes at discrete genomic loci referred to as recombination hotspots. Despite their ubiquitous presence, individual hotspots rapidly lose their activities, and the molecular and evolutionary mechanisms underlying such frequent hotspot turnovers (the so-called "recombination hotspot paradox") remain unresolved. Even though some sequence motifs are significantly associated with hotspots, multiple lines of evidence indicate that factors other than underlying sequences, such as epigenetic modifications, may affect the evolution of recombination hotspots. Thus, identifying epigenetic factors that covary with recombination at fine-scale is a promising step for this important research area. It was previously reported that recombination rates

SUBMITTER: Zeng J 

PROVIDER: S-EPMC4224356 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature