Differential antigen expression profile predicts immunoreactive subset of advanced ovarian cancers.

ABSTRACT: The presence and composition of lymphocytes characterizing an immune response has been connected to prognosis in advanced ovarian cancer. Our aim is to establish novel associations between prognosis and the expression of immune-related genes through a focused screen utilizing publicly available high-throughput assays. We consider transcriptome profiles from n=1137 advanced ovarian cancer patients observed in four separate studies divided into discovery/validation sets (n=503/n=634). We focus on a subset of lymphocyte markers, antigen presentation and processing genes, T cell receptor associated co-stimulatory/repressor genes and cancer testis (CT) antigens. We modeled differential expression and co-expression using these subsets and tested for association with overall survival. Fifteen of

SUBMITTER: Eng KH 

PROVIDER: S-EPMC4224408 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature