Metabolomics as a tool for discovery of biomarkers of autism spectrum disorder in the blood plasma of children.

ABSTRACT:

Background

The diagnosis of autism spectrum disorder (ASD) at the earliest age possible is important for initiating optimally effective intervention. In the United States the average age of diagnosis is 4 years. Identifying metabolic biomarker signatures of ASD from blood samples offers an opportunity for development of diagnostic tests for detection of ASD at an early age.

Objectives

To discover metabolic features present in plasma samples that can discriminate children with ASD from typically developing (TD) children. The ultimate goal is to identify and develop blood-based ASD biomarkers that can be validated in larger clinical trials and deployed to guide individualized therapy and treatment.

Methods

Blood plasma was obtained from children aged 4 to 6, 52 with ASD

SUBMITTER: West PR 

PROVIDER: S-EPMC4224480 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature