Variable Number Tandem Repeat (VNTR) Genotyping of Hydatidiform Mole in Iranian Patients.

ABSTRACT:

Background

Classification of molar gestation into Complete Hydatidiform Mole (CHM) and Partial Hydatidiform Mole (PHM) is done according to clinical, ultrasonographic, histologic and genetic criteria. However, making a distinction between CHM and PHM using histologic criteria alone may be difficult and several studies have shown that misclassifications are frequent, even for experienced pathologists. CHM is the most common precursor to choriocarcinoma and heterozygous moles carry an increased predisposition to transformation.

Methods

Formalin-fixed, paraffin-embedded tissue sections of patients as well as peripheral blood of patients and their partners' were collected in EDTA tubes. Tissue samples were obtained by curettage. Histological evaluation was performed on routine s

SUBMITTER: Pakzad Z 

PROVIDER: S-EPMC4224664 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature