The role of TGF-β signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach.

ABSTRACT:

Background

The immune system is a key biological system present in vertebrates. Exposure to pathogens elicits various defensive immune mechanisms that protect the host from potential threats and harmful substances derived from pathogens such as parasites, bacteria, and viruses. The complex immune system of humans and many other vertebrates can be divided into two major categories: the innate and the adaptive immune systems. At present, analysis of the complex interactions between the two subsystems that regulate host defense and inflammatory responses remains challenging.

Results

Based on time-course microarray data following primary and secondary infection of zebrafish by Candida albicans, we constructed two intracellular protein-protein interaction (PPI) networks for prima

SUBMITTER: Lin C 

PROVIDER: S-EPMC4224695 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature