Seeking the source of Pseudomonas aeruginosa infections in a recently opened hospital: an observational study using whole-genome sequencing.

ABSTRACT:

Objectives

Pseudomonas aeruginosa is a common nosocomial pathogen responsible for significant morbidity and mortality internationally. Patients may become colonised or infected with P. aeruginosa after exposure to contaminated sources within the hospital environment. The aim of this study was to determine whether whole-genome sequencing (WGS) can be used to determine the source in a cohort of burns patients at high risk of P. aeruginosa acquisition.

Study design

An observational prospective cohort study.

Setting

Burns care ward and critical care ward in the UK.

Participants

Patients with >7% total burns by surface area were recruited into the study.

Methods

All patients were screened for P. aeruginosa on admission and samples taken from their immediate e

SUBMITTER: Quick J 

PROVIDER: S-EPMC4225241 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature