Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer.

ABSTRACT:

Background

Nonsteroidal anti-inflammatory drugs (NSAIDs) include aspirin (acetylsalicylic acid, ASA). Long-term use of NSAIDs has been associated with lowered risk of colorectal cancer (CRC), but the use is hampered by adverse effects. Also, the anti-carcinogenic effects of NSAIDs are incompletely understood. Understanding biological effects of NSAIDs may help developing new preventive medical strategies.

Aim

To identify gene-environment interactions between genetic variation and NSAID use in relation to risk of CRC.

Methods

We performed a PubMed literature search and all studies reporting original data on interactions between NSAIDs and polymorphisms in relation to CRC were evaluated.

Results

We found indications that aspirin interacted with rs6983267 close to

SUBMITTER: Andersen V 

PROVIDER: S-EPMC4225470 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature