Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial.

ABSTRACT:

Importance

The disease process leading to clinical type 1 diabetes often starts during the first years of life. Early exposure to complex dietary proteins may increase the risk of β-cell autoimmunity in children at genetic risk for type 1 diabetes. Extensively hydrolyzed formulas do not contain intact proteins.

Objective

To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of diabetes-associated autoantibodies in young children.

Design, setting, and participants

A double-blind randomized clinical trial of 2159 infants with HLA-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited from May 2002 to January 2007 in 78 study centers in 15 countries; 1078 were randomized to be wean

SUBMITTER: Knip M 

PROVIDER: S-EPMC4225544 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature