Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis.

ABSTRACT:

Background

There are increasing studies examining the relationship between the status of H. pylori oipA gene and peptic ulcer disease (PUD) and gastric cancer (GC) but the results turn out to be controversial. We attempted to clarify whether oipA gene status is linked with PUD and/or GC risks.

Methods

A systematically literature search was performed through four electronic databases. According to the specific inclusion and exclusion criteria, seven articles were ultimately available for the meta-analysis of oipA presence/absence with PUD and GC, and eleven articles were included for the meta-analysis of oipA on/off status with PUD and GC.

Results

For the on/off functional status analysis of oipA gene, the "on" status showed significant associations with increased risk

SUBMITTER: Liu J 

PROVIDER: S-EPMC4225565 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature