Gene expression profiling analysis of the putamen for the investigation of compensatory mechanisms in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is affecting 5 million people worldwide, but the response mechanisms of the striatum are still unclear. Therefore, identification of gene expression alterations in the striatum will greatly assist the development of novel therapy strategies.

Methods

We performed a comprehensive gene expression analysis in 15 PD patients and 15 normal controls to identify differentially expressed genes (DEGs) using the expression profile GSE20291 from Gene Expression Omnibus (GEO). Gene Ontology (GO) analysis and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment analysis were used to define functions and pathways altered in PD. Protein-protein interaction network was constructed to find out the modules with close interactions.

Results

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SUBMITTER: Gao L 

PROVIDER: S-EPMC4225573 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature