Relationship Between LAPTM4B Gene Polymorphism and Susceptibility of Malignant Melanoma in Chinese Patients.

ABSTRACT: Lysosomal-associated protein transmembrane 4 beta (LAPTM4B) is known as an oncogene associated with many human malignant tumors. There are two alleles of the gene, LAPTM4B*1 and LAPTM4B*2. Previous studies have shown that LAPTM4B polymorphism contributes to the risk of many cancers. This case-control study was to investigate the relationship between LAPTM4B gene polymorphism and susceptibility of malignant melanoma. The genotypes of LAPTM4B were determined in 617 control subjects and 220 patients with malignant melanoma by utilizing polymerase chain reaction based on specific primers. The genotypic distribution of LAPTM4B and Hardy-Weinberg equilibrium were analyzed by χ (2) test. Odds ratio and 95% confidence interval was calculated by unconditional logistic regression. The distributions

SUBMITTER: Zhang M 

PROVIDER: S-EPMC4225692 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature