Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.

ABSTRACT:

Rationale

Wnt/β-catenin signaling has been implicated in lung fibrosis, but how this occurs and whether expression changes in Wnt pathway components predict disease progression is unknown.

Objectives

To determine whether the Wnt coreceptor Lrp5 drives pulmonary fibrosis in mice and is predictive of disease severity in humans.

Methods

We examined mice with impaired Wnt signaling caused by loss of the Wnt coreceptor Lrp5 in models of lung fibrosis induced by bleomycin or an adenovirus encoding an active form of transforming growth factor (TGF)-β. We also analyzed gene expression in peripheral blood mononuclear cells (PBMC) from patients with idiopathic pulmonary fibrosis (IPF).

Measurements and main results

In patients with IPF, analysis of peripheral blood monon

SUBMITTER: Lam AP 

PROVIDER: S-EPMC4226053 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature