Unknown

Dataset Information

0

Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma.


ABSTRACT: Primary effusion lymphoma (PEL) is an AIDS-defining cancer. All PELs carry Kaposi sarcoma-associated herpesvirus (KSHV). X chromosome-targeted sequencing of PEL identified 34 common missense mutations in 100% of cases. This included a Phe196Ser change in the interleukin 1 receptor-associated kinase 1 (IRAK1). The mutation was verified in primary PEL exudates. IRAK1 is the binding partner of MyD88, which is mutated in a fraction of Waldenström macroglobulinemia. Together, these two mediate toll-like receptor (TLR) signaling. IRAK1 was constitutively phosphorylated in PEL and required for survival, implicating IRAK1 and TLR signaling as a driver pathway in PEL and as a new drug development target.

SUBMITTER: Yang D 

PROVIDER: S-EPMC4226132 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma.

Yang Dongmei D   Chen Wuguo W   Xiong Jie J   Sherrod Carly J CJ   Henry David H DH   Dittmer Dirk P DP  

Proceedings of the National Academy of Sciences of the United States of America 20141023 44


Primary effusion lymphoma (PEL) is an AIDS-defining cancer. All PELs carry Kaposi sarcoma-associated herpesvirus (KSHV). X chromosome-targeted sequencing of PEL identified 34 common missense mutations in 100% of cases. This included a Phe196Ser change in the interleukin 1 receptor-associated kinase 1 (IRAK1). The mutation was verified in primary PEL exudates. IRAK1 is the binding partner of MyD88, which is mutated in a fraction of Waldenström macroglobulinemia. Together, these two mediate toll-l  ...[more]

Similar Datasets

| S-EPMC7296861 | biostudies-literature
| S-EPMC7199399 | biostudies-literature
| S-EPMC6361468 | biostudies-literature
| S-EPMC7845968 | biostudies-literature
| S-EPMC5004954 | biostudies-literature
| S-EPMC6311702 | biostudies-literature
| S-EPMC3868925 | biostudies-literature
| S-EPMC7645656 | biostudies-literature
| S-EPMC38153 | biostudies-other
| S-EPMC5726416 | biostudies-literature