Ontology highlight
ABSTRACT:
SUBMITTER: Yang D
PROVIDER: S-EPMC4226132 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Yang Dongmei D Chen Wuguo W Xiong Jie J Sherrod Carly J CJ Henry David H DH Dittmer Dirk P DP
Proceedings of the National Academy of Sciences of the United States of America 20141023 44
Primary effusion lymphoma (PEL) is an AIDS-defining cancer. All PELs carry Kaposi sarcoma-associated herpesvirus (KSHV). X chromosome-targeted sequencing of PEL identified 34 common missense mutations in 100% of cases. This included a Phe196Ser change in the interleukin 1 receptor-associated kinase 1 (IRAK1). The mutation was verified in primary PEL exudates. IRAK1 is the binding partner of MyD88, which is mutated in a fraction of Waldenström macroglobulinemia. Together, these two mediate toll-l ...[more]