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A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization.

ABSTRACT: Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning.

SUBMITTER: Fairbanks BD 

PROVIDER: S-EPMC4226179 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization.

Fairbanks Benjamin D BD   Schwartz Michael P MP   Halevi Alexandra E AE   Nuttelman Charles R CR   Bowman Christopher N CN   Anseth Kristi S KS  

Advanced materials (Deerfield Beach, Fla.) 20091007 48

Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning. ...[more]

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