Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis.

ABSTRACT:

Objective

In HLA-B27-transgenic rats, the development of a disorder that mimics spondyloarthritis (SpA) is highly correlated with dendritic cell (DC) dysfunction. The present study was undertaken to analyze the underlying mechanisms of this via transcriptome analysis.

Methods

Transcriptome analysis of ex vivo-purified splenic CD103+CD4+ DCs from B27-transgenic rats and control rats was performed. Transcriptional changes in selected genes were confirmed by quantitative reverse transcriptase-polymerase chain reaction. A meta-analysis of our rat data and published data on gene expression in macrophages from ankylosing spondylitis (AS) patients was further performed.

Results

Interferon (IFN) signaling was the most significantly affected pathway in DCs from B27-transgenic

SUBMITTER: Fert I 

PROVIDER: S-EPMC4226235 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature