Prospective Development of Small Molecule Targets to Oncogenic Ras Proteins.

ABSTRACT: Abnormal expression or mutations in Ras proteins has been found in up to 30% of cancer cell types, making them excellent protein models to probe structure-function relationships of cell-signaling processes that mediate cell transformtion. Yet, there has been very little development of therapies to help tackle Ras-related diseased states. The development of small molecules to target Ras proteins to potentially inhibit abnormal Ras-stimulated cell signaling has been conceptualized and some progress has been made over the last 16 or so years. Here, we briefly review studies characterizing Ras protein-small molecule interactions to show the importance and potential that these small molecules may have for Ras-related drug discovery. We summarize recent results, highlighting small molecules that

SUBMITTER: Chandrashekar R 

PROVIDER: S-EPMC4226270 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature