On the prospect of identifying adaptive loci in recently bottlenecked populations.

ABSTRACT: Identifying adaptively important loci in recently bottlenecked populations - be it natural selection acting on a population following the colonization of novel habitats in the wild, or artificial selection during the domestication of a breed - remains a major challenge. Here we report the results of a simulation study examining the performance of available population-genetic tools for identifying genomic regions under selection. To illustrate our findings, we examined the interplay between selection and demography in two species of Peromyscus mice, for which we have independent evidence of selection acting on phenotype as well as functional evidence identifying the underlying genotype. With this unusual information, we tested whether population-genetic-based approaches could have been util

SUBMITTER: Poh YP 

PROVIDER: S-EPMC4226487 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature