Associations between urine excretion of isoflavonoids and cognition in postmenopausal women in the Women's Isoflavone Soy Health clinical trial.

ABSTRACT:

Objectives

To determine effect of change in urine excretion of isoflavonoids on cognitive change.

Design

Post hoc analysis of isoflavonoid exposure (mean 2.7 years) during the randomized, placebo-controlled, double-blind Women's Isoflavone Soy Health trial.

Setting

General community.

Participants

Healthy postmenopausal women (N = 350).

Intervention

Twenty-five grams of isoflavone-rich soy protein (91 mg of aglycone weight isoflavones: 52 mg genistein, 36 mg daidzein, 3 mg glycitein) or milk protein-matched placebo provided daily.

Measurements

Overnight urine excretion, fasting plasma levels of isoflavonoids, and cognitive function measured at baseline and endpoint.

Results

Three hundred women (age: mean 61, range 45-92) completed both cogni

SUBMITTER: St John JA 

PROVIDER: S-EPMC4226524 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature