Common FXIII and fibrinogen polymorphisms in abdominal aortic aneurysms.

ABSTRACT:

Introduction

Abdominal aortic aneurysms (AAA) are characterized by a progressive dilatation of the abdominal aorta, and are associated with a high risk of rupture once the dilatation exceeds 55 mm in diameter. A large proportion of AAA develops an intraluminal thrombus, which contributes to hypoxia, inflammation and tissue degradation. We have previously shown that patients with AAA produce clots with altered structure which is more resistant to fibrinolysis. The aim of this study was to investigate genetic polymorphisms of FXIII and fibrinogen in AAA to identify how changes to these proteins may play a role in the development of AAA.

Methods

Subjects of Western/European descent, ≥55 years of age (520 AAA patients and 449 controls) were genotyped for five polymorphisms (FXII

SUBMITTER: Macrae FL 

PROVIDER: S-EPMC4226572 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature