Preliminary results of a phase II trial of proton radiotherapy for pediatric rhabdomyosarcoma.

ABSTRACT:

Purpose

This prospective phase II study was designed to assess disease control and to describe acute and late adverse effects of treatment with proton radiotherapy in children with rhabdomyosarcoma (RMS).

Patients and methods

Fifty-seven patients with localized RMS (age 21 years or younger) or metastatic embryonal RMS (age 2 to 10 years) were enrolled between February 2005 and August 2012. All patients were treated with chemotherapy based on either vincristine, actinomycin, and cyclophosphamide or vincristine, actinomycin, and ifosfamide-based chemotherapy and proton radiation. Surgical resection was based on tumor site and accessibility. Common Terminology Criteria for Adverse Events, Version 3.0, was used to assess and grade adverse effects of treatment. Concurrent enrollm

SUBMITTER: Ladra MM 

PROVIDER: S-EPMC4226806 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature