Survey of monoclonal antibody disposition in man utilizing a minimal physiologically-based pharmacokinetic model.

ABSTRACT: Minimal physiologically based pharmacokinetic (mPBPK) models provide a simple and sensible approach that incorporates physiological elements into pharmacokinetic (PK) analysis when only plasma data are available. With this modeling concept, a second-generation mPBPK model was further developed with specific accommodations for the unique PK properties of monoclonal antibodies (mAb). This study applied this model to extensively survey mAb PK in man in order to seek general perspectives on mAb distributional and elimination features. Profiles for 72 antibodies were successfully analyzed with this model. The model results provide assessment regarding: (1) predominant clearance site, in plasma or interstitial fluid (ISF); (2) mAb ISF concentrations in two groups of lumped tissues with continuou

SUBMITTER: Cao Y 

PROVIDER: S-EPMC4226811 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature