Incidence and predictors of regimen-modification from first-line antiretroviral therapy in Thailand: a cohort study.

ABSTRACT:

Background

Antiretroviral therapy markedly reduced mortality in HIV-infected individuals. However, in the previous studies, up to 50% of patients are compelled to modify their regimen in middle and low-income countries where salvage drug is still limited. This cohort study aimed to investigate the incidence and predictors of regimen modification from the first-line antiretroviral regimen in northern Thailand.

Methods

All HIV-infected patients starting antiretroviral therapy (ART) with generic drug (GPOvir®; stavudine, lamivudine and nevirapine) at a governmental hospital in northern Thailand from 2002 to 2007 were recruited. Baseline characteristics and detailed information of regimen modification until the end of 2010 were ascertained from cohort database and medical charts

SUBMITTER: Tsuchiya N 

PROVIDER: S-EPMC4226857 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature