Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain.

ABSTRACT:

Background

Sleep quality and genetics may contribute to the etiology of gastrointestinal (GI) symptoms. Individuals with impaired sleep often have a number of associated symptoms including chronic abdominal pain (CAP). The current study examined the interactions of brain-derived neurotrophic factor (BDNF) genotype with sleep quality in persons with CAP and healthy controls. In addition, associations among sleep quality, BDNF genotype, and gene expression were explored in the participants.

Methods

Data were collected on 59 participants (46% male, 61% White, 26.9 ± 6.6 years; CAP (n=19) and healthy controls (n=40)). Participants with CAP reported poorer sleep quality compared to healthy controls. BDNF genotype, categorized as Val/Val homozygotes versus the Met carriers.

Res

SUBMITTER: Reddy SY 

PROVIDER: S-EPMC4226913 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature