Insulator function and topological domain border strength scale with architectural protein occupancy.

ABSTRACT:

Background

Chromosome conformation capture studies suggest that eukaryotic genomes are organized into structures called topologically associating domains. The borders of these domains are highly enriched for architectural proteins with characterized roles in insulator function. However, a majority of architectural protein binding sites localize within topological domains, suggesting sites associated with domain borders represent a functionally different subclass of these regulatory elements. How topologically associating domains are established and what differentiates border-associated from non-border architectural protein binding sites remain unanswered questions.

Results

By mapping the genome-wide target sites for several Drosophila architectural proteins, including previo

SUBMITTER: Van Bortle K 

PROVIDER: S-EPMC4226948 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature