Plasma metabonomics study on Chinese medicine syndrome evolution of heart failure rats caused by LAD ligation.

ABSTRACT:

Background

Chinese medicine syndromes (Zheng) in many disease models are not clearly characterized or validated, and the concepts of Chinese medicine syndromes are confounding and controversial. Metabonomics has been applied to the evaluation and classification of the Chinese medicine syndromes both in clinical and nonclinical studies. In this study, we aim to investigate the evolution of the Chinese medicine syndrome in myocardial infarction induced heart failure and to confirm the feasibility of the Zheng classification by plasma metabonomics in a syndrome and disease combination animal model.

Methods

The heart failure (HF) model was induced by ligation of the left anterior descending coronary artery (LAD) in Sprague-Dawley rats. The rats were divided into the following tw

SUBMITTER: Qiu Q 

PROVIDER: S-EPMC4227006 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature