From cartoon to real time MRI: in vivo monitoring of phagocyte migration in mouse brain.

ABSTRACT: Recent studies have demonstrated that immune cells play an important role in the pathogenesis of many neurological conditions. Immune cells constantly survey the brain microvasculature for irregularities in levels of factors that signal homeostasis. Immune responses are initiated when necessary, resulting in mobilisation of the microglial cells resident in the central nervous system (CNS) and/or of infiltrating peripheral cells. However, little is known about the kinetics of immune cells in healthy and diseased CNS, because it is difficult to perform long-term visualisation of cell motility in live tissue with minimal invasion. Here, we describe highly sensitive in vivo MRI techniques for sequential monitoring of cell migration in the CNS at the single-cell level. We show that MRI combined

SUBMITTER: Mori Y 

PROVIDER: S-EPMC4227027 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature