A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability.

ABSTRACT:

Background

Numerous inflammation-related pathways have been shown to play important roles in atherogenesis. Rapid and efficient assessment of the relative influence of each of those pathways is a challenge in the era of "omics" data generation. The aim of the present work was to develop a network model of inflammation-related molecular pathways underlying vascular disease to assess the degree of translatability of preclinical molecular data to the human clinical setting.

Methods

We constructed and evaluated the Vascular Inflammatory Processes Network (V-IPN), a model representing a collection of vascular processes modulated by inflammatory stimuli that lead to the development of atherosclerosis.

Results

Utilizing the V-IPN as a platform for biological discovery, we ha

SUBMITTER: De Leon H 

PROVIDER: S-EPMC4227037 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature