Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study.

ABSTRACT:

Introduction

Severe infections in intensive care patients show high morbidity and mortality rates. Linezolid is an antimicrobial drug frequently used in critically ill patients. Recent data indicates that there might be high variability of linezolid serum concentrations in intensive care patients receiving standard doses. This study was aimed to evaluate whether standard dosing of linezolid leads to therapeutic serum concentrations in critically ill patients.

Methods

In this prospective observational study, 30 critically ill adult patients with suspected infections received standard dosing of 600 mg linezolid intravenously twice a day. Over 4 days, multiple serum samples were obtained from each patient, in order to determine the linezolid concentrations by liquid chromatogra

SUBMITTER: Zoller M 

PROVIDER: S-EPMC4227093 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature