Cell-permeable bicyclic peptide inhibitors against intracellular proteins.

ABSTRACT: Cyclic peptides have great potential as therapeutic agents and research tools but are generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell-penetrating peptide produces bicyclic peptides that are cell-permeable and retain the ability to recognize specific intracellular targets. Application of this strategy to protein tyrosine phosphatase 1B and a peptidyl-prolyl cis-trans isomerase (Pin1) isomerase resulted in potent, selective, proteolytically stable, and biologically active inhibitors against the enzymes.

SUBMITTER: Lian W 

PROVIDER: S-EPMC4227718 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature