Chromosome conformation maps in fission yeast reveal cell cycle dependent sub nuclear structure.

ABSTRACT: Successful progression through the cell cycle requires spatial and temporal regulation of gene transcript levels and the number, positions and condensation levels of chromosomes. Here we present a high resolution survey of genome interactions in Schizosaccharomyces pombe using synchronized cells to investigate cell cycle dependent changes in genome organization and transcription. Cell cycle dependent interactions were captured between and within S. pombe chromosomes. Known features of genome organization (e.g. the clustering of telomeres and retrotransposon long terminal repeats (LTRs)) were observed throughout the cell cycle. There were clear correlations between transcript levels and chromosomal interactions between genes, consistent with a role for interactions in transcriptional regula

SUBMITTER: Grand RS 

PROVIDER: S-EPMC4227791 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature