Retrograde memory for public events in mild cognitive impairment and its relationship to anterograde memory and neuroanatomy.

ABSTRACT:

Objective

The study characterized the status of retrograde amnesia (RA) in amnestic mild cognitive impairment (MCI).

Method

We measured RA, anterograde amnesia (AA), brain measures, apolipoprotein-E status (ApoE), and conversion to probable Alzheimer's disease (AD) across 3 years in 15 individuals with MCI. We compared the severity of amnesia and brain atrophy in MCI to a group of patients with limited damage to the hippocampus (H) or more extensive damage to the medial temporal lobe (MTL).

Results

The MCI group exhibited modest AA, together with severe RA, covering nearly 4 decades before their diagnosis. Compared with H-MTL patients, the temporal extent of RA was disproportionate to the severity of AA. The MCI group exhibited more modest AA and MTL atrophy than H-MT

SUBMITTER: Smith CN 

PROVIDER: S-EPMC4227913 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature