APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.

ABSTRACT:

Importance

Cognitive impairment is a common and disabling problem in Parkinson disease (PD) that is not well understood and is difficult to treat. Identification of genetic variants that influence the rate of cognitive decline or pattern of early cognitive deficits in PD might provide a clearer understanding of the etiopathogenesis of this important nonmotor feature.

Objective

To determine whether common variation in the APOE, MAPT, and SNCA genes is associated with cognitive performance in patients with PD.

Design, setting, and participants

We studied 1079 PD patients from 6 academic centers in the United States who underwent assessments of memory (Hopkins Verbal Learning Test-Revised [HVLT-R]), attention and executive function (Letter-Number Sequencing Test and Trai

SUBMITTER: Mata IF 

PROVIDER: S-EPMC4227942 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature