Use of a simplified nomogram to individualize digoxin dosing versus standard dosing practices in patients with heart failure.

ABSTRACT:

Study objectives

To compare the frequency of achieving a therapeutic serum digoxin concentration (SDC), defined as 0.5-0.9 ng/ml, by using a simplified nomogram to individualize digoxin dosing with standard dosing practices in patients with heart failure, and to characterize the relationship between genetic polymorphisms of the ABCB1 gene and SDC.

Design

Prospective study with a historical control group.

Setting

Outpatient care center of an urban academic medical center.

Patients

A total of 131 adults with heart failure due to left ventricular dysfunction who were treated with digoxin.

Intervention

Digoxin doses were determined either by the dosing nomogram (65 patients) or standard care (SC; 66 patients) by using historical controls who were randomly se

SUBMITTER: DiDomenico RJ 

PROVIDER: S-EPMC4227958 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature