Myo19 ensures symmetric partitioning of mitochondria and coupling of mitochondrial segregation to cell division.

ABSTRACT: During animal cell division, an actin-based ring cleaves the cell into two. Problems with this process can cause chromosome missegregation and defects in cytoplasmic inheritance and the partitioning of organelles, which in turn are associated with human diseases. Although much is known about how chromosome segregation is coupled to cell division, the way organelles coordinate their inheritance during partitioning to daughter cells is less well understood. Here, using a high-content live-imaging small interfering RNA screen, we identify Myosin-XIX (Myo19) as a novel regulator of cell division. Previously, this actin-based motor was shown to control the interphase movement of mitochondria. Our analysis shows that Myo19 is indeed localized to mitochondria and that its silencing leads to defec

SUBMITTER: Rohn JL 

PROVIDER: S-EPMC4228054 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature