Patterns of genetic variation and the role of selection in HTR1A and HTR1B in macaques (Macaca).

ABSTRACT:

Background

Research has increasingly highlighted the role of serotonin in behavior. However, few researchers have examined serotonin in an evolutionary context, although such research could provide insight into the evolution of important behaviors. The genus Macaca represents a useful model to address this, as this genus shows a wide range of behavioral variation. In addition, many genetic features of the macaque serotonin system are similar to those of humans, and as common models in biomedical research, knowledge of the genetic variation and evolution of serotonin functioning in macaques are particularly relevant for studies of human evolution. Here, we examine the role of selection in the macaque serotonin system by comparing patterns of genetic variation for two genes that code

SUBMITTER: Shattuck MR 

PROVIDER: S-EPMC4228068 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature